2017 Volume 55Annual Issue 4PM-Abstract Pages 375
Silicone resin is applied to many medical devices. However, hydrophobic surface causes thrombus formation when blood contacts with it. To improve the problem, P4 polymer that is the random polymer of 2-Metacryloyloxyethyl phosphorylcoline (MPC), 3-(Metacryloyloxy) propyl-tris (trimetylsilyoxy) silane (MPTSSi) and 3-Methacryloxypropyl trimethyloxysilane (MPTMSi) are expected. Antithrombogenicity of this polymer was shown to be good with in vitro experiments. However, it is not shown sufficiently with in vivo experiments. Then, we attempted in vivo experiments. The artificial silicone vessel coated with the P4 polymer was inserted in the internal jugular vein of goat. However, the silicone vessel was closed few days after surgery. The reason was thought to be insufficient treatment of the end edge of it. We are planning to perform in vivo experiments using P4 polymer-coated canulae of the ventricular assist device.
