Effect of albumin animal species on photosensitization reaction progress and protein oxidization

Abstract

We have developed a new catheter ablation methodology for tachyarrhythmia using photosensitization reaction using talaporfin sodium to reduce complications. We intend to use extracellular singlet oxygen production to realize immediate electrical conduction block by laser irradiation just after the photosensitizer administration. It is reported that the albumin structure different along animal species and binding and cell killing are different. We investigated the photosensitization reaction progress by fluorescence measurement around 700 nm and albumin oxidization by ultraviolet region absorbance using human, bovine, and canine albumin. We found that the albumin oxidization behavior using canine albumin was similar to that of human albumin. The bovine albumin was easily oxidized.