Mitochondrial morphology alterations dependent on actin cytoskeleton by acoustic pulses

Abstract

Shock wave irradiations alter mitochondrial morphologies. In previous studies, shock waves with large energy intensities with peak pressures around 70 MPa were irradiated on cells to observe those alterations. Those alterations were investigated to understand side effects of Extracorporeal Shock Wave Lithotripsy (ESWL). In these 10 years, shock waves with small energy intensity, around 1/10 of those in ESWL, have been demonstrated to induce cellular effects. In our research, shock waves with further small intensity, 1/100 of those in ESWL, are also possible to induce cellular effects. In this study, it has been questioned whether those shock waves with further small intensity could affect mitochondrial morphologies. As results, mitochondrial morphologies altered dependent on actin cytoskeletons.