バイオインフォマティクスから個別化医療へ

抄録

This review discussed recent trends of bioinformatics toward personalized medicine based on projects in which the author participated. First, as an example of a bioinformatics project, an omics analysis on microRNA (miRNA) in hepatocellular carcinoma (HCC) was described. Then, examples in multi-omics approaches followed. One of the features of such approaches is in an integrative analysis of different datasets. Two such examples were given:an analysis on effects of miRNA on neighboring genes and an integrative analysis of miRNA and gene expressions in HCC. The latter evolved into systems biology of cancer, which was described after the multi-omics approaches. Next, a project on exploration of potential biomarkers was described for discontinuation of imatinib in chronic myeloid leukemia. Finally, a brief explanation of the basic principle of next generation sequencer (NGS) was given with its major applications and future perspective.