2018 Volume Annual56 Issue Abstract Pages S118
Background: Although interatrial shunting device (IAS) for heart failure patients has been launched in clinical, its quantitative impact on hemodynamics remains unknown. We developed the circulatory equilibrium framework to estimate the impact of IAS on hemodynamics.
Theoretical consideration: Circulatory equilibrium framework describes hemodynamics by cardiac output curve and venous return surface. We incorporated IAS in it and estimated hemodynamics under IAS.
Method: In 5 mongrel dogs, we connected the atria with a centrifugal pump to mimic IAS hemodynamics. We changed shunt flow and compared estimated hemodynamics with those measured.
Result: The estimated systemic flow (r2=0.93, SEE 12.3 ml/min/kg), pulmonary flow (r2=0.93, SEE 11.7 ml/min/kg), left atrial pressure (r2=0.81, SEE 0.72 mmHg) and right atrial pressure (r2=0.86, SEE 0.59 mmHg) matched well with those measured irrespective of volume status.
Conclusion: Our proposed framework estimated hemodynamics under IAS quantitatively. It may contribute to the safe management of IAS for heart failure patients.
