Bridging to lung transplantation -Its concept and the current status

Abstract

The high waiting-list mortality rate is a critical problem in lung transplantation. One promising approach is to utilize artificial gas-exchange device to bridge to transplant. However, there is no gas-exchange device available for a long-term support (eg, more than a month). The membrane lungs available in the market now are limited to use for up to only several hours, making the bridge-to-transplant concept unrealistic, although some experienced centers have tried to use them on a case-by-case basis. We have started to develop a novel gas-exchange system that consists of silicone-based membrane lungs with new anti-thrombotic polymer coating. Our goal is to offer more opportunities and safer surgical interventions to those who are waiting for lung transplants. We believe the new gas-exchange system allows more mobility and activeness in patients of the waiting period for transplants, which ultimately leads to better overall post-transplant outcome with smooth rehabilitation.