Mechanical evaluation of skin tissues irradiated with low energy ultraviolet

Abstract

The dermis is composed of extracellular matrices and fibroblasts. Collagen and elastin are typical biological fibers in skin extracellular matrix. The rigidity and extensibility of the skin are closely related to the collagen and elastin fibers, respectively. Therefore, the mechanical properties of the skin are determined by the characteristics of both fibers. It is known that ultraviolet exposure is a major risk factor for skin damage which is a cause of wrinkles. Final goal of the present study was to develop an effective medication for the improvement of the extensibility of ultraviolet irradiated skin tissues. The mechanical properties of ultraviolet irradiated skins were evaluated by suction tests. In addition, the similar mechanical tests were conducted for the skins applied an ointment containing elastin component after the ultraviolet irradiation. Based on the obtained data, Young's modulus was calculated to evaluate the changes in the mechanical properties of the ultraviolet irradiated skins.