生体内センサ機能面維持のための電気刺激による血管新生制御

井上 雄介; 横田 知之; 源田 達也; 白石 泰之; 山田 昭博; 平 恭紀; 荒川 友哉; 弓場 充; 軽部 雅人; 斎藤 逸郎; 磯山 隆; 阿部 裕輔; 山家 智之

doi:10.11239/jsmbe.Annual56.S287

Control of angiogenesis using electrical stimulation for implantable sensor

YUSUKE INOUE, TOMOYUKI YOKOTA, TATSUYA GENDA, YASUYUKI SHIRAISHI, AKIHIRO YAMADA, YASUNORI TAIRA, TOMOYA ARAKAWA, MITSURU YUBA, MASATO KARUBE, ITSURO SAITO, TAKASHI ISOYAMA, YUSUKE ABE, TOMOYUKI YAMBE

Author information

YUSUKE INOUE
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo
TOMOYUKI YOKOTA
Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo
TATSUYA GENDA
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
YASUYUKI SHIRAISHI
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
AKIHIRO YAMADA
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
YASUNORI TAIRA
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
TOMOYA ARAKAWA
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
MITSURU YUBA
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
MASATO KARUBE
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University
ITSURO SAITO
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo
TAKASHI ISOYAMA
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo
YUSUKE ABE
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo
TOMOYUKI YAMBE
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University

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2018 Volume Annual56 Issue Abstract Pages S287

DOI https://doi.org/10.11239/jsmbe.Annual56.S287

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Abstract

The purpose of this study is to observe angiogenesis in vivo under application of electric stimulations. We developed an implantable device equipped with a CMOS-camera and electrodes for real-time observation. The device was implanted under the skin of a goat, and applied the electric stimulations for 60 days. The electric stimulations were applied with a 60 kHz sinusoidal waveform and a current density of 300 uA/mm2. Angiogenesis occurred in 94.7um/day in the non-stimulated device, while no angiogenesis was observed in the device without stimulation. These results show that electric stimulations of this condition are effective for suppressing angiogenesis.

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