2018 Volume Annual56 Issue Abstract Pages S81
Metronomic photodynamic therapy (mPDT) is expected as a novel cancer therapy due to its minimal invasiveness. To realize local and long-term photoirradiation to the target tumor, a stable fixation of optical devices in the body is indispensable. In this study, we developed implantable and wirelessly powered optical devices that can be secured onto the biological tissue surfaces without suture. Wirelessly powered LED chips were sealed with polydopamine-modified silicone rubber nanosheets (600 nm thick) to obtain tissue-adhesive optoelectronics. The devices were subcutaneously implanted in the intradermal tumor model mice so that the LEDs were placed just beneath the tumors. After administration of a photosensitizer (photofrin) into the mice, the implanted optical devices locally irradiated the target tumors for 10 days, leading to remarkable tumor regression including complete disappearance. Such a fully-implantable mPDT system is expected to expand the application range of PDT which was thought to be difficult for deep cancers.
