Weekly Interval Training Attenuates the Central Respiratory Drive during Heavy Exercise

抄録

Background: High intensity interval training (HIT) is more effective than continuous training in enhancing cardio-respiratory function and symptom severity in chronic heart failure (CHF). We examined how HIT affects ventilatory regulation. Methods: In 7 healthy subjects, at rest and during exercise at light and heavy intensities, we separately characterized respiratory controller and plant (subsystems) of chemoreflex by changing inspiratory CO2 fraction and by making subjects alter ventilation (VE), respectively. Results: HIT did not affect both subsystems at rest and during light intensity exercise. During heavy intensity exercise, rightward shift of central controller characteristics mainly attributed to lower VE (-9.4%, p<0.01) and higher end tidal PCO2 (+4.4%, p<0.05) after HIT. Conclusion: Weekly high intensity interval training attenuates the respiratory drive during heavy exercise through desensitization of the respiratory central controller. Such mechanism may contribute to favorable effects of HIT in CHF.