An integrated mathematical model including pressure, blood flow, temperature and metabolism in brain

Abstract

A mathematical model of brain's physiological condition was constructed in consideration of the inter relation of intracranial pressure, cerebral blood flow, brain temperature, and cerebral metabolism. This model is necessary for designing and verifying the automatic control system of brain's physiological condition which is being developed to evolve the brain resuscitation.In this paper, the constructed model was analyzed using the almost normal parameters in order to verify the adequacy to use it as a substitute for patients. As the parameters used in this analysis were obtained from more than 10 papers and a few mechanisms of regulating brain's physiological condition were not considered yet in the model, the several analyzed values were inescapably different from the measured value in the previous papers. However the analysis result totally showed no contradiction from the viewpoint of anatomy and physiology. Therefore this model can qualitatively represent normal brain's physiological condition at least.