Development of an optical monitoring system for multi-components in dialysate drainage.

Abstract

To improve QOL of chronic dialysis patients, period of dialysis treatment should be as short as possible. Effect of dialysis is evaluated by blood tests before and after treatment. Because the efficacy cannot be evaluated until the end of dialysis, development of real-time monitoring system of multi-components in dialysate drainage is required to determine appropriate dialysis period.In this study, we tried to predict concentration of urea, uric acid, and creatinine in each aqueous single component solution using FT-IR spectrometer. From the results of the multiple regression analysis with all combinations of ten commercially available LED wavelength, we determined the most appropriate wavelengths combination in order to realize an easy-to-use optical monitoring system using LED. Accuracy of the concentration prediction was evaluated by the standard error of prediction, and the correlation coefficient between actual and predicted concentration. As a result, we confirmed high accuracy in three components concentration prediction.