Development of fine-connective titanium scaffold for bone implant

Abstract

The purpose of this study is to evaluate biocompatible characters of our hybrid-Ti scaffold, the micro-porous and the cell adhesive Ti, for bone substitute. Ti specimens were prepared as the paste by mixing with dental wax. Formed specimens were sintered as test specimens, and bulk Ti was also set as control. Both part of specimens was treated for surface modification as the treated group. 1) Cell adhesion were studied by fibroblast-like cell for 24 and 48 hours. Treated group showed 40% higher of cell adhesion compared to non-treated. And fine cell invasions were observed on porous specimens. 2) Animal implantation on cranium were conducted for 1 and 2 weeks and tested by the pull-out strength. Treated porous specimens showed highest connective strength than non-treated porous spesimens, though bulk specimens showed poor growth between specimens and tissues. Those results indicated the advantages of our hybrid-Ti scaffold as the earlier neointimal scaffold.