Abstract
A flow limit type blood pressure regulator device made up of a diaphragm and a knife edge for occluding a blood vessel is proposed. In the device, blood pressure is regulated by controlling blood flow resistance by the pressure difference between the intravascular pressure and the reference pressure. This device can be applied to realize a constant pressure load and a constant pressure perfusion. In vitro and in vivo performance of the device is examined by a mock circulatory system with this device placed on the descending aorta of dogs. Experimental results obtained indicated that the intravascular pressure was regulated within ±2 mmHg when the flow rate changed less than 1000 ml/min, and that in the animal experiment, the response time was about 5 sec for rapid changes in blood flow rate or peripheral resistance of perfused organs.
