医用電子と生体工学
Online ISSN : 2185-5498
Print ISSN : 0021-3292
アルツハイマー病診断装置の検討
黒目補正法を用いた瞳孔面積長時間測定装置の開発
石川 則夫中市 克己保坂 栄弘太田 善久西村 実植野 彰規南谷 晴之大貫 陽一灰田 宗孝滝沢 俊也篠原 幸人
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1998 年 36 巻 3 号 p. 189-199

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A potential link between Alzheimer's disease and hypersensitive pupil dilation has been reported. Patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in the pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. We have devised a system to measure pupil area stably and intermittently for 60 minutes. This system could potentially be used for Alzheimer's disease diagnosis using this neurobiological test. The system consists of a probe with a high resolution infrared CCD camera and a real time pupil area analysis system using computer imaging processing. Averaging the pupil area during times of eye open, pupillary waves and blinking, and using the constant pupil+iris area to compensate for eye image size variation allows accurate measurement.

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