抄録
The effects of pulsed high-frequency electromagnetic field on the healing of open wound were studied in the rabbit ear by the measurement of the defect area and blood flow of the healing tissue during a period of 28 days. In each ear of 6 rabbits, circular open wounds were made using a 6mm diameter surgical biopsy punch at two sites; the centers of the wounds were located at 52.5mm and 67.5mm proximal from the tip of the ear and 20mm from the lateral edge of the ear. A print coil for the irradiation of electromagnetic field was attached onto one of the ears in each animal; the other ear was attached with no coil to obtain data for comparison. The electromagnetic field having a frequency of 10MHz was intermittently burst for 50μsec with a resting time of 50μsec and was irradiated throughout the experimental period. The source current supplied to the coil was 200mAp-p. Every 7 day after making wound, defect area in each wound was measured with an image analyzer, while blood flow in the healing tissue was measured using a laser Doppler flowmeter having the illuminating area of 2mm in diameter. The defect area was significantly smaller at the irradiated side than at the non-irradiated side at 14 and 21 days. In addition, on the 21st day, the areas at the proximal site were significantly smaller than those at the distal site regardless of irradiation or non-irradiation. The blood flow was highest at the irradiated side both at the distal and proximal sites on the 7th day. In addition, the blood flow at irradiated side of both sites on the 7th day, and of proximal site on the 21st day, were significantly higher than those at the non-irradiated side. These effects indicate that the pulsed high-frequency electromagnetic field enhances the healing of wound due to the increased blood flow in the healing tissue.
