cAMP Signaling Affects Irreversible Attachment During Biofilm Formation by Pseudomonas aeruginosa PAO1

Kaori Ono; Rie Oka; Masanori Toyofuku; Ayane Sakaguchi; Masakaze Hamada; Shiomi Yoshida; Nobuhiko Nomura

doi:10.1264/jsme2.ME13151

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cAMP Signaling Affects Irreversible Attachment During Biofilm Formation by Pseudomonas aeruginosa PAO1

Kaori Ono, Rie Oka, Masanori Toyofuku, Ayane Sakaguchi, Masakaze Hamada, Shiomi Yoshida, Nobuhiko Nomura

著者情報

キーワード: cyclic AMP, attachment, biofilm, Pseudomonas aeruginosa

ジャーナルフリー早期公開

論文ID: ME13151

DOI https://doi.org/10.1264/jsme2.ME13151

この記事には本公開記事があります。

The final version of this article is now available: Vol. 29 (2014), No. 1 pp. 104-106

詳細

抄録

Pseudomonas aeruginosa responds to environmental changes and regulates its life cycle from planktonic to biofilm modes of growth. The control of cell attachment to surfaces is one of the critical processes that determine this transition.Environmental signals are typically relayed to the cytoplasm by second messenger systems. We here demonstrated that the second messenger, cAMP, regulated the attachment of cells. Our results suggest cAMP inhibited the transition from reversible to irreversible attachment. Further analyses revealed that cell surface hydrophobicity, one of the key factors in cell attachment, was altered by cAMP.

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