抄録
It has been well recognized that the heart transplant is one of the most effective ways to cure severe cardiac diseases. However, this treatment has severe limitation, for example, it is very difficult to prepare fresh hearts for transplantation. Recently, tissue engineering approaches such as the cell sheet engineering have been utilized for partial heart diseases such as myocardial infraction. Furthermore, cardiomyocytes derived from iPS cells have been considered to be used to construct engineered cardiac walls. The aim of this study was to understand the fundamental pulsation behavior and mechanism of cardiomyocyte colonies derived from human iPS cells. Effects of co-culture with MSCs on the pulsation were also investigated.
