The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME
Online ISSN : 2424-2829
2016.28
Session ID : 2G42
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2G42 Development of an injectable drug release device using polymeric films
Taro Kondo, Zhaleh Kashkouli Nezhad, Shunichi Tsunajima, Li-Jium Chen, Nobuhiro Nagai, Matsuhiko Nishizawa, Toshiaki Abe, Hirokazu Kaji
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Keywords: Drug-delivery system, Microsphere, Self-deployment, Injectable sheet, Polyethylene glycol
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Abstract
A drug delivery system (DDS) device that consists of microspheres and polymeric film was fabricated and tested. Collagen microspheres (COLs) were embedded in photopolymerized polyethylene glycol dimethacrylate (PEGDM) film. The result showed COLs in the film were uniformly distributed and parts of COLs were exposed on the surface of the device. In vitro release study confirmed that devices could release FITC-dextran (FD40) continuously for over 10 days. It is found that there is a linear relationship between self-deployment time and the number of turns of the sheet. The flexible sheet type device that is injectable by a syringe needle holds great promise to locally deliver drug to specific organs such as eye or bladder.
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© 2016 The Japan Society of Mechanical Engineers
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