抄録
A new simultaneous measuring system using Magnetic Resonance Imaging (MRI) and microdialysis was developed. Because MRI and microdialysis have complementary measuring advantages, the combination of the two methods can provide less invasiveness, high detection sensitivity and multimodality for in vivo biomedical measurement. Using the MRI-Microdialysis simultaneous measuring system, preliminary experiments were performed to examine the rapid effect which MRI has on rat brain metabolism and to analyze the acute physiological response of the brain to oxidative stress. The changes in 5-hydroxyindoleacetic acid (5HIAA), noradrenaline levels in the striatum and 5HIAA, L-aspartic acid and L-asparagine levels in the hypothalamus area were not significant when compared to normal changes in the absence of the MRI sequence. There were no significant changes in 5-HIAA and glutamine levels during the oxidative stress;however, the intensity of the MR image was increased. The increase suggested that a decrease in paramagnetic molecules occurred during the oxidative stress period in the brain.
