Abstract
We present a new approach on the multi-scale, multi-physics computational biomechanics in cardiovascular system (CVS), which is established to be capable to reasonably predict the cardiovascular functions and the biomechanics of arteries and heart under physiological and pathological conditions. This simulator is composed of four computational models involving an anatomically realistic, three-dimensional arterial tree model, a closed-loop, lumped-parameter compartment model of the global CVS, a systematic control model of the autonomic nervous system (ANS) with consideration of the cerebral auto-regulation (CA), and an image-based three-dimensional CFD model of the local arteries and organs. Our results demonstrate that the physiological conditions are of great significance, which points to the importance of the multi-scale and multi-physical modeling of the biomechanics and mechanobiology in the CVS.
