抄録
In this paper, a novel method of platform for regenerative medicine are proposed and experimentally demonstrated. To realize a regenerative medicine, it is key issue to measure not only the cell-cell interactions and communications but the cell-tissue interactions. We have developed single-mask fabrication method for high aspect-ratio embedded micro-channels and high-density arrayed micro-orifices to measure the cell-cell communications for more than several thousand cells simultaneously. To stimuli the target cells and/or to bring foreign substances, such as genes and drugs, into the cells, we have also developed the high-efficiency low-voltage (typically 1.5V) electroporation method and demonstrated its efficiency.
