Abstract
The existence of a transendothelial channel, which is considered to be involved in specific transport of macromolecules is reported. In this study, the generation mechanism of vascular endothelial chained vesicles and the transendothelial channel is theoretically investigated based on minimization of bending and in-plane shear strain energy of the membrane. A system of nonlinear differential equations is derived according to the variational principle and is reduced to a two point boundary value problem. Simulated transendothelial channel changes its shape dramatically form chained vesicular channel to infundibular channel depending on lower opening radius.
