434 Study on Proliferation Promotion Mechanism of Obsteoblasts by Mechanical Vibration Stimulation

Abstract

In the previous study, the mechanical stress affects the proliferation of osteoblast-like MC3T3-El cell. The mechanism of the stress-induced cell proliferation remains unclear. In this study, we examined the involvement of mitogen-activated protein kinase (MAPK) and Akt pathway in the mechanical vibration and observed the alteration of cellular morphology under microscope. On 11 day, the mechanical vibration decreased the expression level of Akt and significantly increased the expression level of phospho-Akt. The area of the osteoblast in the vibration group was larger than the non-vibration group.