抄録
Recently,pathogenesis of aortic valve sclerosis with aging is increasing with development of the aging of the population in Japan.It has been known that endothelial injury is the first step of valvular cholesterosis and the sclerosis.This study considered that some kinds of mechanical stress caused by blood flow e.g.both wall shear stress and structural tensile/compressive stress are one of the factors of endothelial damage.Therefore,in vitro experiment for blood flow was conducted by using a realistic model of human aortic valve and cardiovascular flow simulator based on wind-kessel model and three-dimensional velocity vector distribution and wall shear stress distribution on the model surface were measured by stereo PIV.As a result,swirling flow in a Valsalva sinus model caused by inflow from a part of the jet flow through the valve opening was observed during systole Large shear stress gradient was observed on the surface of the valve basis with valve deformation at the mid systole.
