移植医療のための体外機械灌流における臓器内流動評価

抄録

Organ machine perfusion technology can expand a donor pool for organ transplantation. This technology is able to not only supply the organ with nutrition and oxygen continually through the preservation solution but also evaluate the organ viability. However, the assessment techniques that can evaluate organ viability is not yet established. In this study, the new evaluation techniques using observation methods of flow characteristics in the organ were suggested using vascular resistance measurement and the temperature visualization technique. In particularly, porcine livers were employed to evaluate two warm ischemic conditions (0 and 60 min) differences. This technique is visualized temperature distributions using temperature differences between preservation solution and the livers, and the temperature difference distribution in the liver can estimate flow condition in vessels. As a result, sugessted techniques can indicate the flow condition in vessels and liver viability before implantation.