抄録
Tissue engineering is a promising alternative for treating bone defects. In order to precisely match the irregular boundaries of bone defects as well as facilitate clinical application, scaffold design should be improved. In this study, the scaffold was fabricated by a salt leaching-phase inverse technique of shape memory Polyurethane (SMPU). Different sizes of salts were evaluated in order to obtain scaffolds of different pore sizes. Scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and X-ray micro-computed tomography (μ-CT) demonstrated that the three-dimensional porous polyurethane scaffolds were obtained. Mechanical properties and biocompatibility of scaffolds were analyzed by Compression Test Machine (KES-FB3), thermal mechanical analyzer (TMA) and cell experiment with Osteosarcoma MG-63 cells. Thus, this scaffold represents a potential application prospect in the field of bone tissue engineering.
