Effects of temperature on off-axis fatigue behaviors and the associated constant fatigue life diagrams for unidirectional CFRP laminates have been studied for different fiber orientations and stress ratios. First of all, static tension and compression tests were performed in various fiber orientations at different high temperatures in order to evaluate the temperature dependence of static strengths in tension and compression. Then, off-axis fatigue tests at different stress ratios were performed on specimens with different fiber orientations at different high temperatures, respectively. On the basis of these fatigue test data, the temperature dependence of off-axis fatigue behavior of unidirectional CFRP laminates was elucidated. Applicability of the anisomorphic constant fatigue life diagram approach for prediction of off-axis fatigue life of unidirectional laminates was evaluated by comparing with the experimental results. Finally, the anisomorphic constant fatigue life diagram approach has been extended to a more general engineering model that considers the temperature dependence of static and fatigue strengths. Validity of this extension was evaluated by comparing with the experimental results obtained.