血流によるせん断負荷が血液凝固因子の反応に及ぼす影響

抄録

Thrombus formation in blood pumps is a major problem. It has been reported that the shear rate is closely related to thrombus formation in blood pumps. However, the mechanism of blood coagulation in a shear flow field is not yet fully understood. The purpose of this study is to evaluate the effect of shear loading on the reaction of blood coagulation factors quantitatively. Human blood and porcine blood were used as test blood and loaded shear using a rheometer. After shear loading to the test blood, the activated partial thromboplastin time (APTT), prothrombin time (PT), and reaction time of blood coagulation factors were measured. Results showed that shear loading prolonged the APTT and PT of human blood. Accordingly, the reaction time of human blood coagulation factor V was prolonged. The reaction time of porcine blood coagulation factors after shear loading differed from that of human blood coagulation factors.