Dr. Mainte, an integrated simulator for maintenance optimization of LWRs (Light Water Reactors) is based on PFM (Probabilistic Fracture Mechanics) analyses. The concept of the simulator is to provide a decision-making system to optimize maintenance activities for typical components and piping systems in nuclear power plants totally and quantitatively in terms of safety, availability, economic rationality, environmental impact and social acceptance. For the further improvement of the safety and availability of nuclear power plants, the effect of human error and its reduction on the optimization of maintenance activities have been studied. In addition, an approach of reducing human error is proposed.