B-5 Manipulation of Stretching Chromosomes Form on Microstructures Using Centrifugal Force

Abstract

In this study, we propose a concentrically arrayed micro-mesh structure for high resolution gene analysis using fiber DNA. The micro-mesh structures composed of tapered micro-wires were fabricated by a rotated / inclined exposure method with a single step of the lithography. DNA fibers are constructed over micro-mesh structure array by centrifugal stretching, and can achieve high throughput Fluorescent In Situ Hybridization.