E-1-3 Chromosome Stretching Characterization of High-Throughput DNA Fiber Analysis Device using centrifugal force

Abstract

For gene analysis in clinical diagnosis, we have demonstrated extension of chromosomes by flow induced by a centrifugal force and compartmentalize them at the microfabricated 3 dimensional mesh array. In this study, we analyzed flow field generated by the centrifugal force by finite element method. Then, we evaluated the correlation of the experimental and numerical results. The drag force in the fluid mainly extends the chromosomes on the microchip.