New architectures of manufacturing systems have been proposed aiming at realizing more flexible control structures of manufacturing systems, which can cope with dynamic changes in volume and variety of products, and also with the unscheduled disruptions. They are so called autonomous manufacturing systems like random manufacturing systems, biological manufacturing systems, and holonic manufacturing systems. The purpose of the present research is to develop an integrated process planning and scheduling system, which is applicable to the holonic manufacturing systems. A systematic method is proposed to determine both the machining sequence of the individual products and the production schedules for the multi-products i.e. schedule of the individual machining equipment. A stepwise method of GA (Genetic Algorithm) and load balancing is proposed first for the loading planning of entire products, then a method based on GA and DP (Dynamic Programming) is proposed for the process planning of each product, and finally a method of GA and Dispatching Rule is developed for the production scheduling of the entire products.