Many industrial products or building equipments are standardized but not always designed taking user's sense to ease-of-use into account. The final objective of this research is to establish design system for user friendly engineering products. In the paper, possibility of utilization of electro myoelectric potential in engineering design is investigated. Electromyogram (EMG) occurred in stand-up motion from sitting position on chair under different handrail conditions is measured. Two performance index, median frequency and total sum of spectrum of EMG are examined. They show tendency for load level or degree of fatigue. Some results show effectiveness of usage of EMG information in engineering design or evaluation.