ファウリング防止機能付き人工透析システムのためのローラポンプにおける脈動発生条件の調査

抄録

Haemodialysis (HD) is a treatment that compensates for reduced kidney function and uses a roller pump to circulate blood and dialysate fluid. Wearable artificial kidney (WAK) is designed for continuous 24/7 renal replacement therapy. However, the membrane in the dialyzer becomes clogged with albumin and other plasma proteins over time (fouling), resulting in a decrease in solute permeability. We have developed new roller pumps with the ability to prevent the fouling through pulsation without interrupting treatment. In this study, we built a prototype roller pump to identify the conditions for an optimum pump shape. And we have evaluated the coefficient of variation of the pump pressure under different conditions such as pump geometry and speed. The number of rollers, the angle of the pump shells and the existence of bosses were varied as pump shape. The flow rate was changed between 10 and 200 mL/min. The results showed that the pump shell with bosses and three rollers had a higher pulsation flow.