Abstract
Trabecular bone remodeling correlates well with changes in the mechanical properties of bone.One prime example is the increased fracture risk in osteoporosis,where structural changes by remodeling and decreased bone mass result in changes in the stress distribution of trabecular bone.The stress distribution is also closely associated with bone quality,such as the orientation of the nanoscale biological apatite(BAp) crystallite.We proposed a model of bone remodeling and multi-scale stress analysis of trabecular bone using homogenization techniques,considering the mechanical properties of the BAp crystallite orientation to be anisotropic.In this study,we performed bone remodeling simulation and multi-scale stress analysis to evaluate changes in the fracture risks between healthy and osteoporotic patients.The paper demonstrates that these simulation methods evaluate bone quality,and suggest the usefulness of the mechanical adaptation of morphological changes of trabecular bone as a predictor of fracture risk in osteoporotic patients.
