抄録
In the primary process of thrombus formation, platelets adhere to the vessel wall via an interaction between the glycoprotein Iba (GPIba) on a platelet surface and von Willebrand Factor (vWF) A1 domain on damaged vessel wall. The bond between proteins is reversible and has short life-time. In this study, the platelet adhesion on vessel wall was investigated using kinetic Monte Carlo (kMC) simulation for the multiscale simulation scheme of thrombus formation. The kMC lattice model of a platelet surface with GPIba localization region was constructed in consideration of three kinds of events: GPIba diffusion, bond formation and breakage between GPIba and vWFAl. The number of bonds between GPIba and vWFAl and the adhesion force between a platelet and vessel wall were statistically evaluated. The Worm-like Chain (WLC) model, which has the entropic elasticity, was used as the kinetic model of bond between GPIba and vWFAl and compared with the linear spring model.
