This talk concerns International standardization for threaded fasteners in terms of the quality assurance of threaded fasteners and the reliability of threaded joints. The recent activities in ISO/TC 2 and the related research works are summarized to clarify the inherent characteristics of threaded fasteners, assemblies and joint. The key issues to prevent the accidents induced by the failures of threaded fasteners are advised based on the above characteristics, and the concrete strategies are shown with examples.