Abstract
Numerical simulations were carried out for venous thrombus formation depending on the shear strain rate and its duration time. Blood components were modeled by an assembly of computed particles and the fluid mechanics was solved by the MPS method. A spring force was used to express blood aggregates that form thrombi. In two-dimensional numerical simulations with a stenosed channel, thrombi formed at the stagnation and recirculation region that appeared downstream of the stenosis. About parameters included in a thrombus formation model, the more thrombi were formed with the larger threshold value of the shear strain rate and with the smaller duration time. The distribution of thrombi along the flow channel was qualitatively consistent with a milk clot experiment.
