Abstract
Lymph node (LN) metastasis plays an important role in the development of distant metastasis to vital organs. For LN metastasis, administration of anti-cancer agents is a standard treatment, but it has been a problem about strong side effect and low treatment effect. In the present study, we propose a drug delivery method via lymph network for metastatic LNs. It has a potential to be an effective treatment for targeting LNs and low side effect. We used MXH10/Mo-lpr/lpr mice, which develop systemic swelling of lymph nodes up to 13mm in diameter, similar in size to human lymph node. We demonstrated a molecular can be delivered into the metastatic LN via the lymphatic vessel. Our results may help development of an effective new lymphatic drug delivery method.
