Abstract
The status of tumor-draining lymph nodes (LNs) is a prognostic factor for determining the cancer stage and thus treatment planning. As treatment of lymph node metastasis (LNM), chemotherapy or radiotherapy has been used. However, there have been no reports of evaluation methods of chemotherapy induced anti-tumor effect on metastatic lymph node (MLN) using non-invasive methods. Here we show intranodal pressure (INP) can evaluate the treatment effect on MLN using the mouse model of LNM, MXH10/Mo-/lpr/lpr mice. We found that INP increases in control while chemotherapy induced reduce INP. These results demonstrate that change in INP is related with the anti-tumor effect on LNM. We anticipate that INP is low invasive and may evaluate the antitumor effect on LNM with radiotherapy as well as chemotherapy.
