Abstract
Cancer is one of the major diseases that cause death all over the world, especially via metastasis. Systemic drug administration to treat metastatic lymph nodes are not so effective and cause side effects. In our laboratory, we have studied on a novel drug delivery system, combining nano/microbubbles with ultrasound (US), which shows considerable potential for the delivery of exogenous polymeric molecules into lymph node cells through the lymphatic sinus. In this study, we selected some fluorescent molecules which had different molecular weight (MW) as exogenous molecules, and verified delivery efficiencies depending MW. We found that induction dose into lymph node cells has relationship with molecular weght.
