Mini turbo-pump is used in a wide range of fields, such as water-cooler for personal computer, fuel cells, and ventricular assist device. And there is demand for more compact and higher performance. However, the design method for the mini centrifugal pump is not established because the internal flow condition for these small-sized fluid machines is not clarified and conventional theory is not suitable for small-sized pumps. Then, the semi-open impeller for the mini centrifugal pump with 55mm impeller diameter was adopted for this research. It is important to clarify the suitable design parameters for the mini centrifugal pump with simple structure. Then, the influence of the blade outlet angle, blade number and volute casing size on its performance and internal flow condition were investigated. In the present paper, the high performance design of the mini centrifugal pump is discussed based on the experimental results.