A novel lymphatic treatment method for metastatic lymph node using photothermal therapy with controlled temperature cooling system

抄録

Deep metastatic tumor drainage lymph nodes surgical resection leaves behind structural disruptions and associated risks ^(1,2). Hence, there is need for an alternative method with less disruption and risk. We herein report for the first time, the treatment of metastasis by incorporating lymphatic drug delivery system via the lymphatic network ⁽³⁾. Photothermal therapy (PTT) was deployed by combining biocompatible gold nanorods (GNRs) and near-infrared (NIR) laser irradiation using the lymphatic system administration. By controlling the temperature of the target site skin surface via water cooling system, the damage to the skin during the treatment period was avoided. This also allowed precise control over treatment conditions and planning. The results show that this delivery route is very efficient for non-invasive tumor treatment of lymph node metastasis.