ラット脳実質ひずみ分布の活動電位伝達への影響に関する研究

抄録

Diffuse brain injury is classified by coma time clinically. If coma time is less than 6 hour, it is called concussion, and if coma time is 6 hour or more, it is called Diffuse Axonal Injury (DAI), but the difference of occurrence mechanism of these two injury in neural scale has not been understood yet. Therefore, it is needed to clarify relationship between deformation of brain parenchyma and tolerance of brain function. Although electrophysiological change of axonal function is important, various studies have been conducted based on morphological change of axon. The purpose of this study is to examine relationship between strain distribution and action potential when strain is loaded to corpus callosum of rat brain slice. Firstly, we measured action potential transmitting across corpus callosum when static strain or dynamic strain is loaded. Then we constructed finite element model of rat brain slice to reconstruct strain distribution of the experiment. As a result, we found that action potential is decreased significantly when static strain 0.1 to 0.2 is loaded. And decrease of potential is also observed when dynamic strain was loaded.