Development of a modeled blood which can produce a clot like red thrombus using hyper-coagulable skim milk

Abstract

The purpose of study is developing modeled blood, which is able to produce thrombus formation caused by flow stagnation of blood flow, and evaluating therapeutic performance of embolic device such as intravascular treatment. This study was employed hyper-coagulable skim milk as an agglutinable modeled of blood, a uniform shear was applied by using a cone plate type viscometer. Rheological characteristics of human blood and hyper-coagulable skim milk during red thrombus / milk cot formation were measured. As a result, by changing constituents of hyper-coagulable skim milk such as concentration of skim milk, calcium chloride and rennet, it was able to model agglutination of blood caused by flow stagnation same as red thrombus formation. And the rheological specification of the modeled blood was almost same as the viscosity before agglutination and the first yield viscosity of human blood.