肌のシワ形成メカニズムに関する一考察

抄録

From a biological point of view, wrinkles due to photo-aging are caused by active oxygen and wrinkles due to drying are caused by inflammatory cytokines. However, it is not clear how the mechanism that determines the shape and the size of wrinkles works. Therefore, for the purpose of investigating the mechanism of wrinkle formation, three-layer structure consisting of stratum corneum, epidermis, dermis was modeled with finite element. We assumed an isotropic and homogeneous linear elastic body for each layer of the skin. The buckling analysis was performed under several conditions in which the elastic modulus of each layer of the skin was changed. As a result, wrinkles about 0.1 mm in size were formed in young age and wrinkles about 0.3-0.5 mm in size were formed in old age.