加圧噴霧式定量吸入器(pMDI)用マウスピースの制作と口腔内画像による評価

抄録

The pressurized metered-dose inhaler used for inhalation therapy is believed to cause fewer side effects than oral intake because the drug can be inhaled directly, but side effects occur when the drug adheres to the oral cavity during inhalation. In this study, focusing on the adhesion of drugs to the oral cavity and tongue during inhalation, a mouthpiece that allows the tongue to be placed in a position where it is difficult for drugs to adhere during inhalation was proposed.

In addition, intraoral images were taken during inhalation, and the distance between the soft palate and the tongue, the position of the tongue, and the area of the posterior wall of the pharynx were measured to understand the effect of the mouthpiece. As a result of using the appropriate length mouthpiece, the area of the posterior wall of the pharynx was increased during inhalation, and the tongue was placed in a position where it was difficult for the drug to adhere. However, when the mouthpiece was too long, the tongue's position was not stable due to discomfort, and the area of the posterior wall of the pharynx decreased.