Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : September 05, 2021 - September 08, 2021
Recently, the usage of cell spheroids and organoids has been investigated to improve the biomimicry of microphysiological systems （MPSs）. However, MPSs with cell spheroids need to be formed using conventional culture vessels, and it is difficult to make spheroids uniformly and in large quantities. In this study, we developed a novel multi-organ MPS that enables cell spheroid formation and culture by placing honeycomb microwells （HMWs） at the bottom of the culture chamber. We conducted a functional comparison with HepG2 monolayer culture and spheroids using the MPS. The results showed that the spheroids made with HMW had improved function compared to the cells culture with monolayer.
