流れの中でのがん細胞の電気物性評価のための ROT（electrorotation）デバイスの開発

抄録

Detection of cancer cells is important for cancer diagnosis, and it is necessary to distinguish the cancer cells from healthy cells. The cancer cells can be characterized by electric properties, especially membrane permittivity and cytoplasm conductivity. An electrorotation (ROT) technique is often employed to analyze these properties, but the number of measured data in a single device sometimes becomes an issue. In this study, ROT device with orthogonal rotation axis was developed for measuring electric properties of multiple flowing cancer cells in the device by devising the location of the electrodes. In measurement of HeLa and A549 cells, their electric properties were obtained with high throughput and differences of the properties between these cells could be verified.